Hepatitis E virus infection is a rapidly spreading infection that poses a serious public health threat, particularly to immunocompromised people, pregnant women, and HBV-coinfected people. Depending on the HEV-genotype, Hepatitis E virus is transferred via faecal/oral or zoonotic transmission. Hepatitis E virus, the pathogen that causes the disease, is a little-studied but important infection. Hepatitis E virus usually produces self-limited acute viral hepatitis, but chronic infection with neurological and other extrahepatic symptoms is becoming a major clinical issue. Following the discovery of swine Hepatitis E virus in pigs and proof of its zoonotic potential, Hepatitis E virus strains from more than a dozen different animal species were genetically identified. Hepatitis E virus strains from pigs, rabbits, deer, camels, and rats have been demonstrated to infect humans and overcome species boundaries. Abnormal liver function tests are prevalent during pregnancy. While hepatic damage during pregnancy usually has a minor impact on mother and foetal outcomes, it can occasionally result in serious maternal and foetal morbidity, and even death. We look at the epidemiology, clinical features, diagnosis, and treatment of hepatitis during pregnancy caused by less common pathogens like Epstein–Barr virus, cytomegalovirus, herpes simplex viruses, dengue fever, malaria, leptospirosis, Q fever, typhoid fever, and other uncommon infections, as well as the implications for infants’ breastfeeding. Infection with the hepatitis E virus can induce persistent infections in solid organ transplant recipients, as well as liver damage and cirrhosis. Because infection is typically asymptomatic, under diagnosis is a big issue. Systematic screening may allow for early detection and treatment of liver disease.